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1q47

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[[Image:1q47.gif|left|200px]]
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{{STRUCTURE_1q47| PDB=1q47 | SCENE= }}
{{STRUCTURE_1q47| PDB=1q47 | SCENE= }}
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'''Structure of the Semaphorin 3A Receptor-Binding Module'''
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===Structure of the Semaphorin 3A Receptor-Binding Module===
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==Overview==
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The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. Their distinctive feature is a conserved 500 amino acid semaphorin domain, a ligand-receptor interaction module also present in plexins and scatter-factor receptors. We report the crystal structure of a secreted 65 kDa form of Semaphorin-3A (Sema3A), containing the full semaphorin domain. Unexpectedly, the semaphorin fold is a variation of the beta propeller topology. Analysis of the Sema3A structure and structure-based mutagenesis data identify the neuropilin binding site and suggest a potential plexin interaction site. Based on the structure, we present a model for the initiation of semaphorin signaling and discuss potential similarities with the signaling mechanisms of other beta propeller cell surface receptors, such as integrins and the LDL receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 12925274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12925274}}
==About this Structure==
==About this Structure==
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[[Category: Rajashankar, K R.]]
[[Category: Rajashankar, K R.]]
[[Category: Beta propeller]]
[[Category: Beta propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:50:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:38:58 2008''

Revision as of 11:39, 28 July 2008

Image:1q47.png

Template:STRUCTURE 1q47

Structure of the Semaphorin 3A Receptor-Binding Module

Template:ABSTRACT PUBMED 12925274

About this Structure

1Q47 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the semaphorin-3A receptor binding module., Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Puschel AW, Nikolov DB, Neuron. 2003 Aug 14;39(4):589-98. PMID:12925274

Page seeded by OCA on Mon Jul 28 14:38:58 2008

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