1z8u

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{{STRUCTURE_1z8u| PDB=1z8u | SCENE= }}
{{STRUCTURE_1z8u| PDB=1z8u | SCENE= }}
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'''Crystal structure of oxidized alpha hemoglobin bound to AHSP'''
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===Crystal structure of oxidized alpha hemoglobin bound to AHSP===
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==Overview==
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The synthesis of haemoglobin A (HbA) is exquisitely coordinated during erythrocyte development to prevent damaging effects from individual alpha- and beta-subunits. The alpha-haemoglobin-stabilizing protein (AHSP) binds alpha-haemoglobin (alphaHb), inhibits the ability of alphaHb to generate reactive oxygen species and prevents its precipitation on exposure to oxidant stress. The structure of AHSP bound to ferrous alphaHb is thought to represent a transitional complex through which alphaHb is converted to a non-reactive, hexacoordinate ferric form. Here we report the crystal structure of this ferric alphaHb-AHSP complex at 2.4 A resolution. Our findings reveal a striking bis-histidyl configuration in which both the proximal and the distal histidines coordinate the haem iron atom. To attain this unusual conformation, segments of alphaHb undergo drastic structural rearrangements, including the repositioning of several alpha-helices. Moreover, conversion to the ferric bis-histidine configuration strongly and specifically inhibits redox chemistry catalysis and haem loss from alphaHb. The observed structural changes, which impair the chemical reactivity of haem iron, explain how AHSP stabilizes alphaHb and prevents its damaging effects in cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 15931225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15931225}}
==Disease==
==Disease==
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[[Category: Interaction]]
[[Category: Interaction]]
[[Category: Oxidation]]
[[Category: Oxidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:19:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:39:31 2008''

Revision as of 11:39, 28 July 2008

Image:1z8u.png

Template:STRUCTURE 1z8u

Contents

Crystal structure of oxidized alpha hemoglobin bound to AHSP

Template:ABSTRACT PUBMED 15931225

Disease

Known disease associated with this structure: Erythremias, alpha- OMIM:[141800], Heinz body anemias, alpha- OMIM:[141800], Methemoglobinemias, alpha- OMIM:[141800], Thalassemias, alpha- OMIM:[141800]

About this Structure

1Z8U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem., Feng L, Zhou S, Gu L, Gell DA, Mackay JP, Weiss MJ, Gow AJ, Shi Y, Nature. 2005 Jun 2;435(7042):697-701. PMID:15931225

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