1n1l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1n1l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1l, resolution 2.60&Aring;" /> '''CRYSTAL STRUCTURE OF...)
Next diff →

Revision as of 19:45, 20 November 2007

Image:1n1l.jpg

1n1l, resolution 2.60Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)

Overview

[reaction: see text] In this, the second of two letters, we describe the, elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the, requirements for optimal substitution of the pyrrolidine and lactam, nitrogen atoms. Central to the strategy is the use of rapid iterative, synthesis in conjunction with X-ray crystal structure determination of, ligand-protein complexes.

About this Structure

1N1L is a Protein complex structure of sequences from Hepatitis c virus with ZN and TRL as ligands. Full crystallographic information is available from OCA.

Reference

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents., Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO, Org Lett. 2002 Dec 12;4(25):4479-82. PMID:12465917

Page seeded by OCA on Tue Nov 20 21:52:28 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n1l"
Personal tools