2bvb

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[[Image:2bvb.gif|left|200px]]
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[[Image:2bvb.png|left|200px]]
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{{STRUCTURE_2bvb| PDB=2bvb | SCENE= }}
{{STRUCTURE_2bvb| PDB=2bvb | SCENE= }}
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'''THE C-TERMINAL DOMAIN FROM MICRONEMAL PROTEIN 1 (MIC1) FROM TOXOPLASMA GONDII'''
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===THE C-TERMINAL DOMAIN FROM MICRONEMAL PROTEIN 1 (MIC1) FROM TOXOPLASMA GONDII===
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==Overview==
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Immediately prior to invasion Toxoplasma gondii tachyzoites release a large number of micronemal proteins (TgMICs) that participate in host cell attachment and penetration. The TgMIC4-MIC1-MIC6 complex was the first to be identified in T. gondii and has been recently shown to be critical in invasion. This study establishes that the N-terminal thrombospondin type I repeat-like domains (TSR1-like) from TgMIC1 function as an independent adhesin as well as promoting association with TgMIC4. Using the newly solved three-dimensional structure of the C-terminal domain of TgMIC1 we have identified a novel Galectin-like fold that does not possess carbohydrate binding properties and redefines the architecture of TgMIC1. Instead, the TgMIC1 Galectin-like domain interacts and stabilizes TgMIC6, which provides the basis for a highly specific quality control mechanism for successful exit from the early secretory compartments and for subsequent trafficking of the complex to the micronemes.
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The line below this paragraph, {{ABSTRACT_PUBMED_16166092}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16166092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16166092}}
==About this Structure==
==About this Structure==
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2BVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVB OCA].
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2BVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVB OCA].
==Reference==
==Reference==
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[[Category: Soldati-Favre, D.]]
[[Category: Soldati-Favre, D.]]
[[Category: Mic1,microneme,invasion,adhesion]]
[[Category: Mic1,microneme,invasion,adhesion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:51:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:41:41 2008''

Revision as of 11:41, 28 July 2008

Image:2bvb.png

Template:STRUCTURE 2bvb

THE C-TERMINAL DOMAIN FROM MICRONEMAL PROTEIN 1 (MIC1) FROM TOXOPLASMA GONDII

Template:ABSTRACT PUBMED 16166092

About this Structure

2BVB is a Single protein structure of sequence from Toxoplasma gondii. Full experimental information is available from OCA.

Reference

A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex., Saouros S, Edwards-Jones B, Reiss M, Sawmynaden K, Cota E, Simpson P, Dowse TJ, Jakle U, Ramboarina S, Shivarattan T, Matthews S, Soldati-Favre D, J Biol Chem. 2005 Nov 18;280(46):38583-91. Epub 2005 Sep 15. PMID:16166092

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