2hva

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{{STRUCTURE_2hva| PDB=2hva | SCENE= }}
{{STRUCTURE_2hva| PDB=2hva | SCENE= }}
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'''Solution Structure of the haem-binding protein p22HBP'''
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===Solution Structure of the haem-binding protein p22HBP===
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==Overview==
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The 22 kDa haem-binding protein, p22HBP, is highly expressed in erythropoietic tissues and binds to a range of metallo- and non-metalloporphyrin molecules with similar affinities, suggesting a role in haem regulation or synthesis. We have determined the three-dimensional solution structure of p22HBP and mapped the porphyrin-binding site, which comprises a number of loops and a alpha-helix all located on a single face of the molecule. The structure of p22HBP is related to the bacterial multi-drug resistance protein BmrR, and is the first protein with this fold to be identified in eukaryotes. Strikingly, the porphyrin-binding site in p22HBP is located in a similar position to the drug-binding site of BmrR. These similarities suggest that the broad ligand specificity observed for both BmrR and p22HBP may result from a conserved ligand interaction mechanism. Taken together, these data suggest that the both the fold and its associated function, that of binding to a broad range of small hydrophobic molecules, are ancient, and have been adapted throughout evolution for a variety of purposes.
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{{ABSTRACT_PUBMED_16905148}}
==About this Structure==
==About this Structure==
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2HVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hc6 2hc6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVA OCA].
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2HVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hc6 2hc6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVA OCA].
==Reference==
==Reference==
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[[Category: Haem-binding protein]]
[[Category: Haem-binding protein]]
[[Category: Hydrophobic-ligand binding domain]]
[[Category: Hydrophobic-ligand binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:44:32 2008''

Revision as of 11:44, 28 July 2008

Image:2hva.png

Template:STRUCTURE 2hva

Solution Structure of the haem-binding protein p22HBP

Template:ABSTRACT PUBMED 16905148

About this Structure

2HVA is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 2hc6. Full experimental information is available from OCA.

Reference

A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP., Gell DA, Westman BJ, Gorman D, Liew C, Welch JJ, Weiss MJ, Mackay JP, J Mol Biol. 2006 Sep 15;362(2):287-97. Epub 2006 Aug 14. PMID:16905148

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