1rw2

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{{STRUCTURE_1rw2| PDB=1rw2 | SCENE= }}
{{STRUCTURE_1rw2| PDB=1rw2 | SCENE= }}
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'''Three-dimensional structure of Ku80 CTD'''
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===Three-dimensional structure of Ku80 CTD===
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==Overview==
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The solution structure of Ku80 CTD from residue 566 to 732 has been solved in order to gain insights into the mechanisms of its interactions with other proteins. The structure reveals a topology similar to several common scaffolds for protein-protein interactions, in the absence of significant sequence similarity to these proteins. Conserved surface amino acid residues are clustered on two main surface areas, which are likely involved in mediating interactions between Ku80 and other proteins. The Ku70/Ku80 heterodimer has been shown to be involved in at least three processes, nonhomologous end joining, transcription, and telomere maintenance, and thus it needs to interact with different proteins involved in these different processes. The three-dimensional structure of the Ku80 C-terminal domain and the availability of NMR chemical shift assignments provide a basis for further investigation of the interactions between Ku80 and other proteins in these Ku-dependent cellular functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15016365 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15016365}}
==About this Structure==
==About this Structure==
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1RW2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RW2 OCA].
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1RW2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RW2 OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Structure]]
[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:58:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:46:18 2008''

Revision as of 11:46, 28 July 2008

Image:1rw2.png

Template:STRUCTURE 1rw2

Three-dimensional structure of Ku80 CTD

Template:ABSTRACT PUBMED 15016365

About this Structure

1RW2 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions., Zhang Z, Hu W, Cano L, Lee TD, Chen DJ, Chen Y, Structure. 2004 Mar;12(3):495-502. PMID:15016365

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