This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1n2d
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1n2d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n2d, resolution 2.00Å" /> '''Ternary complex of M...)
Next diff →
Revision as of 19:46, 20 November 2007
|
Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin
Overview
Mlc1p is a calmodulin-like protein from the budding yeast Saccharomyces, cerevisiae, where it has been identified as a subunit of a class V myosin, Myo2p, and a binding partner of an IQGAP-like protein, Iqg1p. Through its, interactions with these two proteins, Mlc1p plays a role in polarized, growth and cytokinesis. Mlc1p has been crystallized in complexes with four, different IQ target motifs from the neck region of Myo2p: IQ2, IQ3, IQ4, and IQ2-IQ3 (referred to as IQ2,3). Electron-density maps for two of the, complexes (Mlc1p-IQ4 and Mlc1p-IQ2,3) were obtained from multiple, anomalous dispersion (MAD) experiments based on selenomethionine, derivatives. The other two structures (Mlc1p-IQ2 and Mlc1p-IQ3) were, determined by molecular replacement using the partially refined structure, of Mlc1p-IQ2,3 as a search model.
About this Structure
1N2D is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V., Terrak M, Otterbein LR, Wu G, Palecanda LA, Lu RC, Dominguez R, Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1882-5. Epub, 2002 Sep 28. PMID:12351846
Page seeded by OCA on Tue Nov 20 21:53:25 2007
