1z4l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1z4l.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1z4l.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1z4l| PDB=1z4l | SCENE= }}
{{STRUCTURE_1z4l| PDB=1z4l | SCENE= }}
-
'''Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 5'-monophosphate'''
+
===Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 5'-monophosphate===
-
==Overview==
+
<!--
-
The human mitochondrial deoxyribonucleotidase catalyzes the dephosphorylation of thymidine and deoxyuridine monophosphates and participates in the regulation of the dTTP pool in mitochondria. We present seven structures of the inactive D41N variant of this enzyme in complex with thymidine 3'-monophosphate, thymidine 5'-monophosphate, deoxyuridine 5'-monophosphate, uridine 5'-monophosphate, deoxyguanosine 5'-monophosphate, uridine 2'-monophosphate, and the 5'-monophosphate of the nucleoside analog 3'-deoxy 2'3'-didehydrothymidine, and we draw conclusions about the substrate specificity based on comparisons with enzyme activities. We show that the enzyme's specificity for the deoxyribo form of nucleoside 5'-monophosphates is due to Ile-133, Phe-49, and Phe-102, which surround the 2' position of the sugar and cause an energetically unfavorable environment for the 2'-hydroxyl group of ribonucleoside 5'-monophosphates. The close binding of the 3'-hydroxyl group of nucleoside 5'-monophosphates to the enzyme indicates that nucleoside analog drugs that are substituted with a bulky group at this position will not be good substrates for this enzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16004879}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16004879 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16004879}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Wallden, K.]]
[[Category: Wallden, K.]]
[[Category: Alfa beta fold]]
[[Category: Alfa beta fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:10:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:49:39 2008''

Revision as of 11:49, 28 July 2008

Image:1z4l.png

Template:STRUCTURE 1z4l

Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 5'-monophosphate

Template:ABSTRACT PUBMED 16004879

About this Structure

1Z4L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase., Wallden K, Ruzzenente B, Rinaldo-Matthis A, Bianchi V, Nordlund P, Structure. 2005 Jul;13(7):1081-8. PMID:16004879

Page seeded by OCA on Mon Jul 28 14:49:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z4l"
Personal tools