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1ujw

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{{STRUCTURE_1ujw| PDB=1ujw | SCENE= }}
{{STRUCTURE_1ujw| PDB=1ujw | SCENE= }}
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'''Structure of the complex between BtuB and Colicin E3 Receptor binding domain'''
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===Structure of the complex between BtuB and Colicin E3 Receptor binding domain===
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==Overview==
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Cellular import of colicin E3 is initiated by the Escherichia coli outer membrane cobalamin transporter, BtuB. The 135-residue 100-A coiled-coil receptor-binding domain (R135) of colicin E3 forms a 1:1 complex with BtuB whose structure at a resolution of 2.75 A is reported. Binding of R135 to the BtuB extracellular surface (DeltaG(o) = -12 kcal mol(-1)) is mediated by 27 residues of R135 near the coiled-coil apex. Formation of the R135-BtuB complex results in unfolding of R135 N- and C-terminal ends, inferred to be important for unfolding of the colicin T-domain. Small conformational changes occur in the BtuB cork and barrel domains but are insufficient to form a translocation channel. The absence of a channel and the peripheral binding of R135 imply that BtuB serves to bind the colicin, and that the coiled-coil delivers the colicin to a neighboring outer membrane protein for translocation, thus forming a colicin translocon. The translocator was concluded to be OmpF from the occlusion of OmpF channels by colicin E3.
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The line below this paragraph, {{ABSTRACT_PUBMED_14528295}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14528295 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14528295}}
==About this Structure==
==About this Structure==
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[[Category: Beta-barrel]]
[[Category: Beta-barrel]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:19:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:50:06 2008''

Revision as of 11:50, 28 July 2008

Image:1ujw.png


PDB ID 1ujw

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1ujw, resolution 2.75Å ()
Ligands: , , , ,
Related: 1nqe, 1jch
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of the complex between BtuB and Colicin E3 Receptor binding domain

Template:ABSTRACT PUBMED 14528295

About this Structure

1UJW is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of BtuB with bound colicin E3 R-domain implies a translocon., Kurisu G, Zakharov SD, Zhalnina MV, Bano S, Eroukova VY, Rokitskaya TI, Antonenko YN, Wiener MC, Cramer WA, Nat Struct Biol. 2003 Nov;10(11):948-54. Epub 2003 Oct 5. PMID:14528295

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