2jqc

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{{STRUCTURE_2jqc| PDB=2jqc | SCENE= }}
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'''A L-amino acid mutant of a D-amino acid containing conopeptide'''
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===A L-amino acid mutant of a D-amino acid containing conopeptide===
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==Overview==
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Cone snails, a group of gastropod animals that inhabit tropical seas, are capable of producing a mixture of peptide neurotoxins, namely conotoxins, for defense and predation. Conotoxins are mainly disulfide-rich short peptides that act on different ion channels, neurotransmitter receptors, or transporters in the nervous system. They exhibit highly diverse compositions, structures, and biological functions. In this work, a novel Cys-free 15-residue conopeptide from Conus marmoreus was purified and designated as conomarphin. Conomarphin is unique because of its d-configuration Phe at the third residue from the C-terminus, which was identified using HPLC by comparing native conomarphin fragments and the corresponding synthetic peptides cleaved by different proteases. Surprisingly, the cDNA-encoded precursor of conomarphin was found to share the conserved signal peptide with other M-superfamily conotoxins, clearly indicating that conomarphin should belong to the M-superfamily, although conomarphin shares no homology with other six-Cys-containing M-superfamily conotoxins. Furthermore, NMR spectroscopy experiments established that conomarphin adopts a well-defined structure in solution, with a tight loop in the middle of the peptide and a short 3(10)-helix at the C-terminus. By contrast, no loop in l-Phe13-conomarphin was found, which suggests that d-Phe13 is essential for the structure of conomarphin. In conclusion, conomarphin may represent a new conotoxin family, whose biological activity remains to be identified.
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(as it appears on PubMed at http://www.pubmed.gov), where 18355315 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18355315}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQC OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQC OCA].
==Reference==
==Reference==
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[[Category: Mr12]]
[[Category: Mr12]]
[[Category: Nmr solution structure]]
[[Category: Nmr solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:01:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:51:09 2008''

Revision as of 11:51, 28 July 2008

Image:2jqc.png

Template:STRUCTURE 2jqc

A L-amino acid mutant of a D-amino acid containing conopeptide

Template:ABSTRACT PUBMED 18355315

About this Structure

Full experimental information is available from OCA.

Reference

Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus., Han Y, Huang F, Jiang H, Liu L, Wang Q, Wang Y, Shao X, Chi C, Du W, Wang C, FEBS J. 2008 Mar 18;. PMID:18355315

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