1n5z

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[[Image:1n5z.gif|left|200px]]
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{{STRUCTURE_1n5z| PDB=1n5z | SCENE= }}
{{STRUCTURE_1n5z| PDB=1n5z | SCENE= }}
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'''Complex structure of Pex13p SH3 domain with a peptide of Pex14p'''
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===Complex structure of Pex13p SH3 domain with a peptide of Pex14p===
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==Overview==
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While the function of most small signaling domains is confined to binary ligand interactions, the peroxisomal Pex13p SH3 domain has the unique capacity of binding to two different ligands, Pex5p and Pex14p. We have used this domain as a model to decipher its structurally independent ligand binding sites. By the combined use of X-ray crystallography, NMR spectroscopy, and circular dichroism, we show that the two ligands bind in unrelated conformations to patches located at opposite surfaces of this SH3 domain. Mutations in the Pex13p SH3 domain that abolish interactions within the Pex13p-Pex5p interface specifically impair PTS1-dependent protein import into yeast peroxisomes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12453410}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12453410 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12453410}}
==About this Structure==
==About this Structure==
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[[Category: Pxxp motif]]
[[Category: Pxxp motif]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:08:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:51:27 2008''

Revision as of 11:51, 28 July 2008

Image:1n5z.png

Template:STRUCTURE 1n5z

Complex structure of Pex13p SH3 domain with a peptide of Pex14p

Template:ABSTRACT PUBMED 12453410

About this Structure

1N5Z is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain., Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M, Mol Cell. 2002 Nov;10(5):1007-17. PMID:12453410

Page seeded by OCA on Mon Jul 28 14:51:27 2008

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