1qox

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[[Image:1qox.gif|left|200px]]
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{{STRUCTURE_1qox| PDB=1qox | SCENE= }}
{{STRUCTURE_1qox| PDB=1qox | SCENE= }}
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'''BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS'''
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===BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS===
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==Overview==
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Family 1 of glycosyl hydrolases is a large and biologically important group of enzymes. A new three-dimensional structure of this family, beta-glucosidase from Bacillus circulans sp. alkalophilus is reported here. This is the first structure of beta-glucosidase from an alkaliphilic organism. The model was determined by the molecular replacement method and refined to a resolution of 2.7 A. The quaternary structure of B. circulans sp. alkalophilus beta-glucosidase is an octamer and subunits of the octamer show a similar (beta/alpha)(8) barrel fold to that previously reported for other family 1 enzymes. The crystal structure suggested that Cys169 in the active site is substituted. The Cys169 is located near the putative acid/base catalyst Glu166 and it may contribute to the high pH optimum of the enzyme. The crystal structure also revealed that the asymmetric unit contains two octamers which have a clear binding interaction with each other. The ability of the octamers to link with each other suggested that beta-glucosidase from Bacillus circulans sp. alkalophilus is able to form long polymeric assemblies, at least in the crystalline state.
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(as it appears on PubMed at http://www.pubmed.gov), where 10675298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10675298}}
==About this Structure==
==About this Structure==
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[[Category: Cellulose degradation]]
[[Category: Cellulose degradation]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:32:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:53:50 2008''

Revision as of 11:53, 28 July 2008

Image:1qox.png

Template:STRUCTURE 1qox

BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS

Template:ABSTRACT PUBMED 10675298

About this Structure

1QOX is a Single protein structure of sequence from Bacillus circulans. Full crystallographic information is available from OCA.

Reference

The crystal structure of beta-glucosidase from Bacillus circulans sp. alkalophilus: ability to form long polymeric assemblies., Hakulinen N, Paavilainen S, Korpela T, Rouvinen J, J Struct Biol. 2000 Feb;129(1):69-79. PMID:10675298

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