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2qze

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{{STRUCTURE_2qze| PDB=2qze | SCENE= }}
{{STRUCTURE_2qze| PDB=2qze | SCENE= }}
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'''Monoclinic Mimivirus Capping Enzyme Triphosphatase.'''
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===Monoclinic Mimivirus Capping Enzyme Triphosphatase.===
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==Overview==
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The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to the cysteinyl-phosphatase RTPases of their metazoan host organisms. The origins of DNA virus RTPases are unclear because they are structurally uncharacterized. Mimivirus, a giant virus of amoeba, resembles poxviruses in having a trifunctional capping enzyme composed of a metal-dependent RTPase module fused to guanylyltransferase (GTase) and guanine-N7 methyltransferase domains. The crystal structure of mimivirus RTPase reveals a minimized tunnel fold and an active site strikingly similar to that of Cet1. Unlike homodimeric fungal RTPases, mimivirus RTPase is a monomer. The mimivirus TTM-type RTPase-GTase fusion resembles the capping enzymes of amoebae, providing evidence that the ancestral large DNA virus acquired its capping enzyme from a unicellular host.
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(as it appears on PubMed at http://www.pubmed.gov), where 18400173 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18400173}}
==About this Structure==
==About this Structure==
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[[Category: Tunnel]]
[[Category: Tunnel]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:27:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:13 2008''

Revision as of 11:59, 28 July 2008

Image:2qze.png

Template:STRUCTURE 2qze

Monoclinic Mimivirus Capping Enzyme Triphosphatase.

Template:ABSTRACT PUBMED 18400173

About this Structure

2QZE is a Single protein structure of sequence from Mimivirus. Full crystallographic information is available from OCA.

Reference

Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain., Benarroch D, Smith P, Shuman S, Structure. 2008 Apr;16(4):501-12. PMID:18400173

Page seeded by OCA on Mon Jul 28 14:59:13 2008

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