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2old

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{{STRUCTURE_2old| PDB=2old | SCENE= }}
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'''Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form'''
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===Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form===
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==Overview==
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A Bence Jones protein isolated in the early 1960s from a patient (initials KWR) suffering from plasma-cell dyscrasia was crystallized and its structure was analyzed in four different unit cells by X-ray diffraction. The final models of the molecule in all crystal forms were virtually the same, although the elbow angles relating the constant and variable domains of the Bence Jones dimers varied over a range of 10 degrees. The tetragonal form had an R factor of 22.6% and an R(free) of 28.3% at 2.2 A resolution. Phosphate or sulfate ions (depending on the crystallization conditions) were found in the antigen-combining sites in all crystals, as well as an unidentified ligand tightly bound in the hydrophobic 'deep pocket' beneath the antigen-binding site. The ligand was treated as a phenol molecule. Two trigonal crystal forms were among those solved. One was grown at pH 4.0 and the other was only obtained after sitting for more than eight months at room temperature. The latter crystal was composed of molecules that were degraded in their constant domains. Both low pH and proteolytic degradation of constant domains are known to promote the polymerization of some Bence Jones proteins into amyloid fibrils. Indeed, in both trigonal crystal forms the molecules are organized with pseudo-hexagonal symmetry about the unique crystallographic axes in a manner suggestive of such fibrils. The arrangement of Bence Jones dimers is also consistent with other observations regarding Bence Jones amyloid-fibril structure and current models.
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(as it appears on PubMed at http://www.pubmed.gov), where 17582169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17582169}}
==About this Structure==
==About this Structure==
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[[Category: McPherson, A.]]
[[Category: McPherson, A.]]
[[Category: Immunoglobulin light chain]]
[[Category: Immunoglobulin light chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:59:51 2008''

Revision as of 11:59, 28 July 2008

Image:2old.png

Template:STRUCTURE 2old

Bence Jones KWR Protein- Immunoglobulin Light Chain Dimer, P3(2)21 Crystal Form

Template:ABSTRACT PUBMED 17582169

About this Structure

Full crystallographic information is available from OCA.

Reference

Bence Jones KWR protein structures determined by X-ray crystallography., Makino DL, Henschen-Edman AH, Larson SB, McPherson A, Acta Crystallogr D Biol Crystallogr. 2007 Jul;63(Pt 7):780-92. Epub 2007, Jun 15. PMID:17582169

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