This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2r5p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2r5p.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2r5p.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2r5p| PDB=2r5p | SCENE= }}
{{STRUCTURE_2r5p| PDB=2r5p | SCENE= }}
-
'''Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir'''
+
===Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir===
-
==Overview==
+
<!--
-
Fourteen subtype B and C protease variants have been engineered in an effort to study whether the preexistent baseline polymorphisms, by themselves or in combination with drug resistance mutations, differentially alter the biochemical and structural features of the subtype C protease when compared with those of subtype B protease. The kinetic studies performed in this work showed that the preexistent polymorphisms in subtype C protease, by themselves, do not provide for a greater level of resistance. Inhibition analysis with eight clinically used protease inhibitors revealed that the natural polymorphisms found in subtype C protease, in combination with drug resistance mutations, can influence enzymatic catalytic efficiency and inhibitor resistance. Structural analyses of the subtype C protease bound to nelfinavir and indinavir showed that these inhibitors form similar interactions with the residues in the active site of subtype B and C proteases. It also revealed that the naturally occurring polymorphisms could alter the position of the outer loops of the subtype C protease, especially the 60's loop.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18092815}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18092815 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18092815}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Protease]]
[[Category: Protease]]
[[Category: Viral protein]]
[[Category: Viral protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:17:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:01:22 2008''

Revision as of 12:01, 28 July 2008

Image:2r5p.png

Template:STRUCTURE 2r5p

Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir

Template:ABSTRACT PUBMED 18092815

About this Structure

2R5P is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease., Coman RM, Robbins AH, Fernandez MA, Gilliland CT, Sochet AA, Goodenow MM, McKenna R, Dunn BM, Biochemistry. 2008 Jan 15;47(2):731-43. Epub 2007 Dec 20. PMID:18092815

Page seeded by OCA on Mon Jul 28 15:01:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r5p"
Personal tools