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2k0b

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{{STRUCTURE_2k0b| PDB=2k0b | SCENE= }}
{{STRUCTURE_2k0b| PDB=2k0b | SCENE= }}
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'''NMR structure of the UBA domain of p62 (SQSTM1)'''
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===NMR structure of the UBA domain of p62 (SQSTM1)===
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==Overview==
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The ubiquitin associated domain of p62 is a small three-helix bundle of approximately 50 residues that mediates the recognition of polyubiquitin chains and ubiquitylated substrates. The solution structure of a 52 residue construct containing this domain has been characterized using heteronuclear nuclear magnetic resonance (NMR) methods. The resulting ensemble of NMR-derived structures was used in molecular dynamics (MD) simulations to investigate the equilibrium conformation and dynamics of this domain. NOE and (15)N relaxation data have been used to validate the structural ensemble produced by the MD simulations and show a good correlation for residues in regions of secondary structure. A similar approach was taken using an ensemble of structures from the MD simulations to calculate electronic circular dichroism (CD) and IR spectra from first principles with an encouraging correlation with the experimental CD and IR data. Proteins 2008. (c) 2007 Wiley-Liss, Inc.
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(as it appears on PubMed at http://www.pubmed.gov), where 17932931 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17932931}}
==About this Structure==
==About this Structure==
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2K0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0B OCA].
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2K0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0B OCA].
==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:27:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:03:41 2008''

Revision as of 12:03, 28 July 2008

Image:2k0b.png

Template:STRUCTURE 2k0b

NMR structure of the UBA domain of p62 (SQSTM1)

Template:ABSTRACT PUBMED 17932931

About this Structure

2K0B is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Conformation and dynamics of the three-helix bundle UBA domain of p62 from experiment and simulation., Evans CL, Long JE, Gallagher TR, Hirst JD, Searle MS, Proteins. 2007 Oct 11;71(1):227-240. PMID:17932931

Page seeded by OCA on Mon Jul 28 15:03:41 2008

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