2g01

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[[Image:2g01.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2g01| PDB=2g01 | SCENE= }}
{{STRUCTURE_2g01| PDB=2g01 | SCENE= }}
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'''Pyrazoloquinolones as Novel, Selective JNK1 inhibitors'''
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===Pyrazoloquinolones as Novel, Selective JNK1 inhibitors===
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==Overview==
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A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency.
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(as it appears on PubMed at http://www.pubmed.gov), where 16527482 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16527482}}
==About this Structure==
==About this Structure==
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[[Category: Jnk1]]
[[Category: Jnk1]]
[[Category: Protein kinase jnk1 inhibitor]]
[[Category: Protein kinase jnk1 inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:31:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:09:55 2008''

Revision as of 12:09, 28 July 2008

Template:STRUCTURE 2g01

Pyrazoloquinolones as Novel, Selective JNK1 inhibitors

Template:ABSTRACT PUBMED 16527482

About this Structure

2G01 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors., Liu M, Xin Z, Clampit JE, Wang S, Gum RJ, Haasch DL, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G, Bioorg Med Chem Lett. 2006 May 15;16(10):2590-4. Epub 2006 Mar 9. PMID:16527482

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