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1owx

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{{STRUCTURE_1owx| PDB=1owx | SCENE= }}
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'''Solution structure of the C-terminal RRM of human La (La225-334)'''
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===Solution structure of the C-terminal RRM of human La (La225-334)===
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==Overview==
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The La protein is an important component of ribonucleoprotein complexes that acts mainly as an RNA chaperone to facilitate correct processing and maturation of RNA polymerase III transcripts, but can also stimulate translation initiation. We report here the structure of the C-terminal domain of human La, which comprises an atypical RNA recognition motif (La225-334) and a long unstructured C-terminal tail. The central beta sheet of La225-334 reveals novel features: the putative RNA binding surface is formed by a five-stranded beta sheet and, strikingly, is largely obscured by a long C-terminal alpha helix that encompasses a recently identified nuclear retention element. Contrary to previous observations, we find that the La protein does not contain a dimerization domain.
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{{ABSTRACT_PUBMED_12842046}}
==About this Structure==
==About this Structure==
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1OWX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWX OCA].
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1OWX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWX OCA].
==Reference==
==Reference==
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[[Category: Manolaridis, I.]]
[[Category: Manolaridis, I.]]
[[Category: Rrm]]
[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:22:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:10:12 2008''

Revision as of 12:10, 28 July 2008

Image:1owx.png

Template:STRUCTURE 1owx

Solution structure of the C-terminal RRM of human La (La225-334)

Template:ABSTRACT PUBMED 12842046

About this Structure

1OWX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element., Jacks A, Babon J, Kelly G, Manolaridis I, Cary PD, Curry S, Conte MR, Structure. 2003 Jul;11(7):833-43. PMID:12842046

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