2alv

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{{STRUCTURE_2alv| PDB=2alv | SCENE= }}
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'''X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors'''
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===X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors===
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==Overview==
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Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16250632 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16250632}}
==About this Structure==
==About this Structure==
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[[Category: Proteinase]]
[[Category: Proteinase]]
[[Category: Sar]]
[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:12:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:11:09 2008''

Revision as of 12:11, 28 July 2008

Image:2alv.png

Template:STRUCTURE 2alv

X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors

Template:ABSTRACT PUBMED 16250632

About this Structure

2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632

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