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1ull

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[[Image:1ull.jpg|left|200px]]
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{{STRUCTURE_1ull| PDB=1ull | SCENE= }}
{{STRUCTURE_1ull| PDB=1ull | SCENE= }}
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'''RNA APTAMER COMPLEXED WITH HIV-1 REV PEPTIDE, NMR, 7 STRUCTURES'''
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===RNA APTAMER COMPLEXED WITH HIV-1 REV PEPTIDE, NMR, 7 STRUCTURES===
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==Overview==
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A combined NMR-molecular dynamics approach has been applied to determine the solution structure of a HIV-1 17-mer rev peptide bound to its 35-mer high affinity RNA aptamer binding site. Complex formation involves adaptive binding with the alpha-helical arginine-rich basic rev peptide targeting a widened RNA major groove centred about adjacent G.A and reversed A.A mismatches. We have also identified a U AU triple in the aptamer complex with the Hoogsteen-paired uracil base sandwiched between two arginine side chains. The intermolecular contacts identified in the aptamer complex readily account for the consequences of peptide and RNA mutations, as well as the results of previous in vitro selection experiments. The details of molecular recognition associated with targeting by rev of its high affinity RNA binding sites open new opportunities for structure-based drug design strategies.
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(as it appears on PubMed at http://www.pubmed.gov), where 8946856 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8946856}}
==About this Structure==
==About this Structure==
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1ULL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULL OCA].
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1ULL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULL OCA].
==Reference==
==Reference==
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[[Category: Rev peptide-rna recognition]]
[[Category: Rev peptide-rna recognition]]
[[Category: Uau base triple]]
[[Category: Uau base triple]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:23:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:20:13 2008''

Revision as of 12:20, 28 July 2008

Image:1ull.png

Template:STRUCTURE 1ull

RNA APTAMER COMPLEXED WITH HIV-1 REV PEPTIDE, NMR, 7 STRUCTURES

Template:ABSTRACT PUBMED 8946856

About this Structure

1ULL is a Single protein structure of sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

Deep penetration of an alpha-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex., Ye X, Gorin A, Ellington AD, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1026-33. PMID:8946856

Page seeded by OCA on Mon Jul 28 15:20:13 2008

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