2a7r

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{{STRUCTURE_2a7r| PDB=2a7r | SCENE= }}
{{STRUCTURE_2a7r| PDB=2a7r | SCENE= }}
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'''Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)'''
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===Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)===
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==Overview==
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Guanosine monophosphate reductase (GMPR) catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides. Here, we report the first crystal structure of human GMP reductase 2 (hGMPR2) in complex with GMP at 3.0 A resolution. The protein forms a tetramer composed of subunits adopting the ubiquitous (alpha/beta)8 barrel fold. Interestingly, the substrate GMP is bound to hGMPR2 through interactions with Met269, Ser270, Arg286, Ser288, and Gly290; this makes the conformation of the adjacent flexible binding region (residues 268-289) fixed, much like a door on a hinge. Structure comparison and sequence alignment analyses show that the conformation of the active site loop (residues 179-187) is similar to those of hGMPR1 and inosine monophosphate dehydrogenases (IMPDHs). We propose that Cys186 is the potential active site, and that the conformation of the loop (residues 129-133) suggests a preference for the coenzyme NADPH over NADH. This structure provides important information towards understanding the functions of members of the GMPR family.
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(as it appears on PubMed at http://www.pubmed.gov), where 16359702 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16359702}}
==About this Structure==
==About this Structure==
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[[Category: Zheng, M.]]
[[Category: Zheng, M.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:42:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:27:59 2008''

Revision as of 12:28, 28 July 2008

Image:2a7r.png

Template:STRUCTURE 2a7r

Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2)

Template:ABSTRACT PUBMED 16359702

About this Structure

2A7R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP., Li J, Wei Z, Zheng M, Gu X, Deng Y, Qiu R, Chen F, Ji C, Gong W, Xie Y, Mao Y, J Mol Biol. 2006 Feb 3;355(5):980-8. Epub 2005 Dec 1. PMID:16359702

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