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1ooz

From Proteopedia

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[[Image:1ooz.gif|left|200px]]
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{{STRUCTURE_1ooz| PDB=1ooz | SCENE= }}
{{STRUCTURE_1ooz| PDB=1ooz | SCENE= }}
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'''Deletion mutant of SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART'''
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===Deletion mutant of SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART===
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==Overview==
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Succinyl-CoA:3-ketoacid CoA transferase (SCOT; EC 2.8.3.5) activates the acetoacetate in ketone bodies by transferring the CoA group from succinyl-CoA to acetoacetate to produce acetoacetyl-CoA and succinate. In the reaction, a glutamate residue at the active site of the enzyme forms a thioester bond with CoA and in this form the enzyme is subject to autolytic fragmentation. The crystal structure of pig heart SCOT has been solved and refined to 1.7 A resolution in a new crystal form. The structure shows the active-site glutamate residue in a conformation poised for autolytic fragmentation, with its side chain accepting one hydrogen bond from Asn281 and another from its own amide N atom. However, the conformation of this glutamate side chain would have to change for the residues that are conserved in the CoA transferases (Gln99, Gly386 and Ala387) to participate in stabilizing the tetrahedral transition states of the catalytic mechanism. The structures of a deletion mutant in two different crystal forms were also solved.
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(as it appears on PubMed at http://www.pubmed.gov), where 15388917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15388917}}
==About this Structure==
==About this Structure==
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[[Category: Wolodko, W T.]]
[[Category: Wolodko, W T.]]
[[Category: Alpha/beta protein]]
[[Category: Alpha/beta protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:06:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:29:06 2008''

Revision as of 12:29, 28 July 2008

Image:1ooz.png

Template:STRUCTURE 1ooz

Deletion mutant of SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART

Template:ABSTRACT PUBMED 15388917

About this Structure

1OOZ is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of the CoA transferase from pig heart to 1.7 A resolution., Coros AM, Swenson L, Wolodko WT, Fraser ME, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1717-25. Epub 2004, Sep 23. PMID:15388917

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