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1sl0

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[[Image:1sl0.gif|left|200px]]
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{{Seed}}
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[[Image:1sl0.png|left|200px]]
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{{STRUCTURE_1sl0| PDB=1sl0 | SCENE= }}
{{STRUCTURE_1sl0| PDB=1sl0 | SCENE= }}
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'''Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide'''
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===Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide===
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==Overview==
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Ultraviolet-induced DNA damage poses a lethal block to replication. To understand the structural basis for this, we determined crystal structures of a replicative DNA polymerase from bacteriophage T7 in complex with nucleotide substrates and a DNA template containing a cis-syn cyclobutane pyrimidine dimer (CPD). When the 3' thymine is the templating base, the CPD is rotated out of the polymerase active site and the fingers subdomain adopts an open orientation. When the 5' thymine is the templating base, the CPD lies within the polymerase active site where it base-pairs with the incoming nucleotide and the 3' base of the primer, while the fingers are in a closed conformation. These structures reveal the basis for the strong block of DNA replication that is caused by this photolesion.
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The line below this paragraph, {{ABSTRACT_PUBMED_15235589}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15235589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15235589}}
==About this Structure==
==About this Structure==
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[[Category: Open]]
[[Category: Open]]
[[Category: Thymine dimer]]
[[Category: Thymine dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:50:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:29:25 2008''

Revision as of 12:29, 28 July 2008

Image:1sl0.png

Template:STRUCTURE 1sl0

Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide

Template:ABSTRACT PUBMED 15235589

About this Structure

1SL0 is a Protein complex structure of sequences from Enterobacteria phage t7 and Escherichia coli. Full crystallographic information is available from OCA.

Reference

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7., Li Y, Dutta S, Doublie S, Bdour HM, Taylor JS, Ellenberger T, Nat Struct Mol Biol. 2004 Aug;11(8):784-90. Epub 2004 Jul 4. PMID:15235589

Page seeded by OCA on Mon Jul 28 15:29:25 2008

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