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1y7q

From Proteopedia

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[[Image:1y7q.gif|left|200px]]
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{{Seed}}
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[[Image:1y7q.png|left|200px]]
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{{STRUCTURE_1y7q| PDB=1y7q | SCENE= }}
{{STRUCTURE_1y7q| PDB=1y7q | SCENE= }}
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'''Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain'''
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===Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain===
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==Overview==
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Retroviral assembly is driven by multiple interactions mediated by the Gag polyprotein, the main structural component of the forming viral shell. Critical determinants of Gag oligomerization are contained within the C-terminal domain (CTD) of the capsid protein, which also harbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable Gag. An unexpected clue about the MHR function in retroviral assembly emerges from the structure of the zinc finger-associated SCAN domain we describe here. The SCAN dimer adopts a fold almost identical to that of the retroviral capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like element between the monomers. Mutations in retroviral capsid proteins and functional data suggest that a SCAN-like MHR-swapped CTD dimer forms during immature particle assembly. In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance.
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The line below this paragraph, {{ABSTRACT_PUBMED_15629724}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15629724 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15629724}}
==About this Structure==
==About this Structure==
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1Y7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].
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1Y7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7Q OCA].
==Reference==
==Reference==
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[[Category: Retroviral capsid c-terminal domain]]
[[Category: Retroviral capsid c-terminal domain]]
[[Category: Scan domain]]
[[Category: Scan domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:58:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:31:31 2008''

Revision as of 12:31, 28 July 2008

Image:1y7q.png

Template:STRUCTURE 1y7q

Mammalian SCAN domain dimer is a domain-swapped homologue of the HIV capsid C-terminal domain

Template:ABSTRACT PUBMED 15629724

About this Structure

1Y7Q is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain., Ivanov D, Stone JR, Maki JL, Collins T, Wagner G, Mol Cell. 2005 Jan 7;17(1):137-43. PMID:15629724

Page seeded by OCA on Mon Jul 28 15:31:31 2008

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