2hbn

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{{STRUCTURE_2hbn| PDB=2hbn | SCENE= }}
{{STRUCTURE_2hbn| PDB=2hbn | SCENE= }}
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'''Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex'''
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===Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex===
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==Overview==
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The crystal structure of the Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been solved to 1.55 A. This G-quadruplex contains five Tl+ ions, three of which are interspersed between adjacent G-quartet planes and one in each of the two thymine loops. The structure displays a high degree of similarity to the K+ crystal structure [Haider et al. (2002), J. Mol. Biol., 320, 189-200], including the number and location of the monovalent cation binding sites. The highly isomorphic nature of the two structures, which contain such a large number of monovalent binding sites (relative to nucleic acid content), verifies the ability of Tl+ to mimic K+ in nucleic acids. Information from this report confirms and extends the assignment of 205Tl resonances from a previous report [Gill et al. (2005), J. Am. Chem. Soc., 127, 16 723-16 732] where 205Tl NMR was used to study monovalent cation binding to this G-quadruplex. The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale.
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{{ABSTRACT_PUBMED_16945956}}
==About this Structure==
==About this Structure==
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[[Category: G-quadruplex]]
[[Category: G-quadruplex]]
[[Category: Thallium]]
[[Category: Thallium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:32:04 2008''

Revision as of 12:32, 28 July 2008

Image:2hbn.png

Template:STRUCTURE 2hbn

Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex

Template:ABSTRACT PUBMED 16945956

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex., Gill ML, Strobel SA, Loria JP, Nucleic Acids Res. 2006;34(16):4506-14. Epub 2006 Aug 31. PMID:16945956

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