1poz

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[[Image:1poz.jpg|left|200px]]
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{{Seed}}
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[[Image:1poz.png|left|200px]]
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{{STRUCTURE_1poz| PDB=1poz | SCENE= }}
{{STRUCTURE_1poz| PDB=1poz | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44'''
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===SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44===
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==Overview==
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Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding domain and a formerly unidentified protein fold. Moreover, the disposition of key N-glycosylation sites reveals how specific sugar chains could alter both the affinity and avidity of CD44 HA binding. Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies.
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The line below this paragraph, {{ABSTRACT_PUBMED_14992719}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14992719 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14992719}}
==About this Structure==
==About this Structure==
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1POZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA].
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1POZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA].
==Reference==
==Reference==
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[[Category: Hyaluronan-binding domain]]
[[Category: Hyaluronan-binding domain]]
[[Category: Link module]]
[[Category: Link module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:33:02 2008''

Revision as of 12:33, 28 July 2008

Image:1poz.png

Template:STRUCTURE 1poz

SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44

Template:ABSTRACT PUBMED 14992719

About this Structure

1POZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44., Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG, Mol Cell. 2004 Feb 27;13(4):483-96. PMID:14992719

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