1n9a

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[[Image:1n9a.gif|left|200px]]
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{{Seed}}
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[[Image:1n9a.png|left|200px]]
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{{STRUCTURE_1n9a| PDB=1n9a | SCENE= }}
{{STRUCTURE_1n9a| PDB=1n9a | SCENE= }}
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'''Farnesyltransferase complex with tetrahydropyridine inhibitors'''
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===Farnesyltransferase complex with tetrahydropyridine inhibitors===
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==Overview==
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Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered bioavailable aryl tetrahydropyridines that are potent in cell culture. The design, synthesis, SAR and biological properties of these compounds will be discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_12657283}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12657283 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657283}}
==About this Structure==
==About this Structure==
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Tetrahydropyridine]]
[[Category: Tetrahydropyridine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:15:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:33:48 2008''

Revision as of 12:33, 28 July 2008

Image:1n9a.png

Template:STRUCTURE 1n9a

Farnesyltransferase complex with tetrahydropyridine inhibitors

Template:ABSTRACT PUBMED 12657283

About this Structure

1N9A is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency., Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1363-6. PMID:12657283

Page seeded by OCA on Mon Jul 28 15:33:48 2008

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