2cky

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[[Image:2cky.gif|left|200px]]
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{{STRUCTURE_2cky| PDB=2cky | SCENE= }}
{{STRUCTURE_2cky| PDB=2cky | SCENE= }}
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'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''
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===Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand===
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==Overview==
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Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.
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(as it appears on PubMed at http://www.pubmed.gov), where 16675665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16675665}}
==About this Structure==
==About this Structure==
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[[Category: Thore, S.]]
[[Category: Thore, S.]]
[[Category: Nucleic acid]]
[[Category: Nucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:23:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:37:41 2008''

Revision as of 12:37, 28 July 2008

Image:2cky.png

Template:STRUCTURE 2cky

Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand

Template:ABSTRACT PUBMED 16675665

About this Structure

2CKY is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665

Page seeded by OCA on Mon Jul 28 15:37:41 2008

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