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2ol3

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[[Image:2ol3.gif|left|200px]]
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{{STRUCTURE_2ol3| PDB=2ol3 | SCENE= }}
{{STRUCTURE_2ol3| PDB=2ol3 | SCENE= }}
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'''crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule'''
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===crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule===
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==Overview==
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Binding degeneracy is thought to constitute a fundamental property of the T-cell antigen receptor (TCR), yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and a peptide (pBM8) bound to the H-2K(bm8) major histocompatibility complex (MHC) molecule, and compared it with the structures of the BM3.3 TCR bound to H-2K(b) molecules loaded with two peptides that had a minimal level of primary sequence identity with pBM8. Our findings provide a refined structural view of the basis of BM3.3 TCR cross-reactivity and a structural explanation for the long-standing paradox that a TCR antigen-binding site can be both specific and degenerate. We also measured the thermodynamic features and biological penalties that incurred during cross-recognition. Our data illustrate the difficulty for a given TCR in adapting to distinct peptide-MHC surfaces while still maintaining affinities that result in functional in vivo responses. Therefore, when induction of protective effector T cells is used as the ultimate criteria for adaptive immunity, TCRs are probably much less degenerate than initially assumed.
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{{ABSTRACT_PUBMED_17363906}}
==About this Structure==
==About this Structure==
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[[Category: T cell receptor]]
[[Category: T cell receptor]]
[[Category: Tcr-pmhc complex]]
[[Category: Tcr-pmhc complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:08:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:38:08 2008''

Revision as of 12:38, 28 July 2008

Image:2ol3.png

Template:STRUCTURE 2ol3

crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule

Template:ABSTRACT PUBMED 17363906

About this Structure

2OL3 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?, Mazza C, Auphan-Anezin N, Gregoire C, Guimezanes A, Kellenberger C, Roussel A, Kearney A, van der Merwe PA, Schmitt-Verhulst AM, Malissen B, EMBO J. 2007 Apr 4;26(7):1972-83. Epub 2007 Mar 15. PMID:17363906

Page seeded by OCA on Mon Jul 28 15:38:08 2008

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