1ooi

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[[Image:1ooi.jpg|left|200px]]
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{{Seed}}
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[[Image:1ooi.png|left|200px]]
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{{STRUCTURE_1ooi| PDB=1ooi | SCENE= }}
{{STRUCTURE_1ooi| PDB=1ooi | SCENE= }}
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'''Crystal structure of LUSH from Drosophila melanogaster at pH 6.5'''
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===Crystal structure of LUSH from Drosophila melanogaster at pH 6.5===
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==Overview==
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We have solved the high-resolution crystal structures of the Drosophila melanogaster alcohol-binding protein LUSH in complex with a series of short-chain n-alcohols. LUSH is the first known nonenzyme protein with a defined in vivo alcohol-binding function. The structure of LUSH reveals a set of molecular interactions that define a specific alcohol-binding site. A group of amino acids, Thr57, Ser52 and Thr48, form a network of concerted hydrogen bonds between the protein and the alcohol that provides a structural motif to increase alcohol-binding affinity at this site. This motif seems to be conserved in a number of mammalian ligand-gated ion channels that are directly implicated in the pharmacological effects of alcohol. Further, these sequences are found in regions of ion channels that are known to confer alcohol sensitivity. We suggest that the alcohol-binding site in LUSH represents a general model for alcohol-binding sites in proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12881720 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12881720}}
==About this Structure==
==About this Structure==
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[[Category: Lush]]
[[Category: Lush]]
[[Category: Odorant-binding protein]]
[[Category: Odorant-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:06:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:39:28 2008''

Revision as of 12:39, 28 July 2008

Image:1ooi.png

Template:STRUCTURE 1ooi

Crystal structure of LUSH from Drosophila melanogaster at pH 6.5

Template:ABSTRACT PUBMED 12881720

About this Structure

1OOI is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:12881720

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