1pjl

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{{STRUCTURE_1pjl| PDB=1pjl | SCENE= }}
{{STRUCTURE_1pjl| PDB=1pjl | SCENE= }}
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'''Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+'''
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===Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+===
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==Overview==
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The catalytic activity of malic enzyme (ME), a member of a new class of oxidative decarboxylases, requires the presence of divalent cations (Mn(2+), Mg(2+), and others). The crystal structure at 2.9 A resolution of human mitochondrial NAD(+)-dependent malic enzyme in a ternary complex with NAD(+) and the lanthanide ion Lu(3+), which has similar radius as Mn(2+), reveals a new conformation of the enzyme. The active site in this ternary complex is in an open form, while the organization of the tetramer of the enzyme actually resembles that with a closed active site. The Lu(3+) ion is bound to the enzyme at the same site as Mn(2+). Kinetic studies showed that Lu(3+) is a potent inhibitor of both the human NAD(P)(+)-dependent ME and the NADP(+)-dependent ME from pigeon liver, and is competitive with respect to the divalent cation, consistent with the structural information.
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(as it appears on PubMed at http://www.pubmed.gov), where 10913357 is the PubMed ID number.
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==Disease==
==Disease==
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[[Category: Yang, Z.]]
[[Category: Yang, Z.]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:09:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:40:14 2008''

Revision as of 12:40, 28 July 2008

Image:1pjl.png

Template:STRUCTURE 1pjl

Contents

Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+

Template:ABSTRACT PUBMED 10913357

Disease

Known disease associated with this structure: Epilepsy, idopathic generalized, susceptibility to OMIM:[154270]

About this Structure

1PJL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent and competitive inhibition of malic enzymes by lanthanide ions., Yang Z, Batra R, Floyd DL, Hung HC, Chang GG, Tong L, Biochem Biophys Res Commun. 2000 Aug 2;274(2):440-4. PMID:10913357

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