1nql

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[[Image:1nql.jpg|left|200px]]
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{{STRUCTURE_1nql| PDB=1nql | SCENE= }}
{{STRUCTURE_1nql| PDB=1nql | SCENE= }}
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'''Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.'''
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===Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.===
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==Overview==
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Epidermal growth factor (EGF) receptor is the prototype of the ErbB (HER) family receptor tyrosine kinases (RTKs), which regulate cell growth and differentiation and are implicated in many human cancers. EGF activates its receptor by inducing dimerization of the 621 amino acid EGF receptor extracellular region. We describe the 2.8 A resolution crystal structure of this entire extracellular region (sEGFR) in an unactivated state. The structure reveals an autoinhibited configuration, where the dimerization interface recently identified in activated sEGFR structures is completely occluded by intramolecular interactions. To activate the receptor, EGF binding must promote a large domain rearrangement that exposes this dimerization interface. This contrasts starkly with other RTK activation mechanisms and suggests new approaches for designing ErbB receptor antagonists.
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The line below this paragraph, {{ABSTRACT_PUBMED_12620237}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12620237 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12620237}}
==Disease==
==Disease==
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[[Category: Growth factor]]
[[Category: Growth factor]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:51:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:43:06 2008''

Revision as of 12:43, 28 July 2008

Image:1nql.png

Template:STRUCTURE 1nql

Contents

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

Template:ABSTRACT PUBMED 12620237

Disease

Known disease associated with this structure: Hypomagnesemia 4, renal OMIM:[131530]

About this Structure

1NQL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization., Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA, Mol Cell. 2003 Feb;11(2):507-17. PMID:12620237

Page seeded by OCA on Mon Jul 28 15:43:06 2008

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