360d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:360d.gif|left|200px]]
+
{{Seed}}
 +
[[Image:360d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_360d| PDB=360d | SCENE= }}
{{STRUCTURE_360d| PDB=360d | SCENE= }}
-
'''STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION'''
+
===STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION===
-
==Overview==
+
<!--
-
The crystal structure is reported of a complex between an ethyl derivative of the minor-groove drug furamidine and the dodecanucleotide duplex d(CGCGAATTCGCG)2, which has been refined to 1.85 A resolution and an R factor of 16.6% for data collected at -173 degreesC. An exceptionally large number (220) of water molecules have been located. The majority of these occur in the first coordination shell of solvation. There are extensive networks of connected waters, both in the major and minor grooves. In particular, there are 21 water molecules associated with the minor-groove drug, via hydrogen bonds from the four charged nitrogen atoms. One cluster of four waters is situated in the groove itself; the majority are on the outer edge of the groove, and serve to bridge between the outward-directed drug nitrogen atoms and backbone phosphate oxygen atoms. These bridges are both intra- and inter-strand, with the net effect that the outer edge of the drug molecule is covered by ribbons of water molecules.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9611230}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9611230 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9611230}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:17:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:45:11 2008''

Revision as of 12:45, 28 July 2008

Image:360d.png

Template:STRUCTURE 360d

STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION

Template:ABSTRACT PUBMED 9611230

About this Structure

Full crystallographic information is available from OCA.

Reference

Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex., Guerri A, Simpson IJ, Neidle S, Nucleic Acids Res. 1998 Jun 15;26(12):2873-8. PMID:9611230

Page seeded by OCA on Mon Jul 28 15:45:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/360d"
Personal tools