1ycr

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{{STRUCTURE_1ycr| PDB=1ycr | SCENE= }}
{{STRUCTURE_1ycr| PDB=1ycr | SCENE= }}
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'''MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53'''
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===MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53===
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==Overview==
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The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix. The interface relies on the steric complementarity between the MDM2 cleft and the hydrophobic face of the p53 alpha helix and, in particular, on a triad of p53 amino acids-Phe19, Trp23, and Leu26-which insert deep into the MDM2 cleft. These same p53 residues are also involved in transactivation, supporting the hypothesis that MDM2 inactivates p53 by concealing its transactivation domain. The structure also suggests that the amphipathic alpha helix may be a common structural motif in the binding of a diverse family of transactivation factors to the TATA-binding protein-associated factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 8875929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8875929}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:09:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:47:35 2008''

Revision as of 12:47, 28 July 2008

Image:1ycr.png

Template:STRUCTURE 1ycr

MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53

Template:ABSTRACT PUBMED 8875929

About this Structure

1YCR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain., Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP, Science. 1996 Nov 8;274(5289):948-53. PMID:8875929

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