2no3

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[[Image:2no3.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2no3| PDB=2no3 | SCENE= }}
{{STRUCTURE_2no3| PDB=2no3 | SCENE= }}
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'''Novel 4-anilinopyrimidines as potent JNK1 Inhibitors'''
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===Novel 4-anilinopyrimidines as potent JNK1 Inhibitors===
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==Overview==
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A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.
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(as it appears on PubMed at http://www.pubmed.gov), where 17107797 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17107797}}
==About this Structure==
==About this Structure==
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[[Category: Jnk1]]
[[Category: Jnk1]]
[[Category: Jnk1 inhibitor]]
[[Category: Jnk1 inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:41:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:58:24 2008''

Revision as of 12:58, 28 July 2008

Template:STRUCTURE 2no3

Novel 4-anilinopyrimidines as potent JNK1 Inhibitors

Template:ABSTRACT PUBMED 17107797

About this Structure

2NO3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies., Liu M, Wang S, Clampit JE, Gum RJ, Haasch DL, Rondinone CM, Trevillyan JM, Abad-Zapatero C, Fry EH, Sham HL, Liu G, Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. Epub 2006 Nov 2. PMID:17107797

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