2fe4

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{{STRUCTURE_2fe4| PDB=2fe4 | SCENE= }}
{{STRUCTURE_2fe4| PDB=2fe4 | SCENE= }}
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'''The crystal structure of human neuronal Rab6B in its inactive GDP-bound form'''
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===The crystal structure of human neuronal Rab6B in its inactive GDP-bound form===
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==Overview==
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The Rab small G-protein family plays important roles in eukaryotes as regulators of vesicle traffic. In Rab proteins, the hydrolysis of GTP to GDP is coupled with association with and dissociation from membranes. Conformational changes related to their different nucleotide states determine their effector specificity. The crystal structure of human neuronal Rab6B was solved in its 'inactive' (with bound MgGDP) and 'active' (MgGTPgammaS-bound) forms to 2.3 and 1.8 A, respectively. Both crystallized in space group P2(1)2(1)2(1), with similar unit-cell parameters, allowing the comparison of both structures without packing artifacts. Conformational changes between the inactive GDP and active GTP-like state are observed mainly in the switch I and switch II regions, confirming their role as a molecular switch. Compared with other Rab proteins, additional changes are observed in the Rab6 subfamily-specific RabSF3 region that might contribute to the specificity of Rab6 for its different effector proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_16790928}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16790928 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16790928}}
==About this Structure==
==About this Structure==
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[[Category: Tcherniuk, F.]]
[[Category: Tcherniuk, F.]]
[[Category: Protein-nucleotide complex]]
[[Category: Protein-nucleotide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:47:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:03:49 2008''

Revision as of 13:03, 28 July 2008

Image:2fe4.png

Template:STRUCTURE 2fe4

The crystal structure of human neuronal Rab6B in its inactive GDP-bound form

Template:ABSTRACT PUBMED 16790928

About this Structure

2FE4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human neuronal Rab6B in the active and inactive form., Garcia-Saez I, Tcherniuk S, Kozielski F, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):725-33. Epub 2006, Jun 20. PMID:16790928

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