1ywh

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[[Image:1ywh.gif|left|200px]]
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{{Seed}}
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[[Image:1ywh.png|left|200px]]
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{{STRUCTURE_1ywh| PDB=1ywh | SCENE= }}
{{STRUCTURE_1ywh| PDB=1ywh | SCENE= }}
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'''crystal structure of urokinase plasminogen activator receptor'''
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===crystal structure of urokinase plasminogen activator receptor===
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==Overview==
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We report the crystal structure of a soluble form of human urokinase-type plasminogen activator receptor (uPAR/CD87), which is expressed at the invasive areas of the tumor-stromal microenvironment in many human cancers. The structure was solved at 2.7 A in association with a competitive peptide inhibitor of the urokinase-type plasminogen activator (uPA)-uPAR interaction. uPAR is composed of three consecutive three-finger domains organized in an almost circular manner, which generates both a deep internal cavity where the peptide binds in a helical conformation, and a large external surface. This knowledge combined with the discovery of a convergent binding motif shared by the antagonist peptide and uPA allowed us to build a model of the human uPA-uPAR complex. This model reveals that the receptor-binding module of uPA engages the uPAR central cavity, thus leaving the external receptor surface accessible for other protein interactions (vitronectin and integrins). By this unique structural assembly, uPAR can orchestrate the fine interplay with the partners that are required to guide uPA-focalized proteolysis on the cell surface and control cell adhesion and migration.
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The line below this paragraph, {{ABSTRACT_PUBMED_15861141}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15861141 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15861141}}
==About this Structure==
==About this Structure==
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[[Category: Three-finger fold]]
[[Category: Three-finger fold]]
[[Category: Upar]]
[[Category: Upar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:52:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:04:01 2008''

Revision as of 13:04, 28 July 2008

Image:1ywh.png

Template:STRUCTURE 1ywh

crystal structure of urokinase plasminogen activator receptor

Template:ABSTRACT PUBMED 15861141

About this Structure

1YWH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide., Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A, EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7. PMID:15861141

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