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1xhp

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{{STRUCTURE_1xhp| PDB=1xhp | SCENE= }}
{{STRUCTURE_1xhp| PDB=1xhp | SCENE= }}
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'''Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae'''
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===Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae===
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==Overview==
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Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis of a protein-free U2-U6 complex from Saccharomyces cerevisiae. The observed folding of the U2-U6 complex is a four-helix junction, in which the catalytically important AGC triad base-pairs only within U6 and not with U2. The base-pairing of the AGC triad extends the U6 intramolecular stem-loop (U6 ISL), and the NMR structure of this extended U6 ISL reveals structural similarities with domain 5 of group II self-splicing introns. The observed conformation of the four-helix junction could be relevant to the first, but not the second, step of splicing and may help to position the U6 ISL adjacent to the 5' splice site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15543154 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15543154}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].
==Reference==
==Reference==
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[[Category: Rna stem-loop]]
[[Category: Rna stem-loop]]
[[Category: U6 rna]]
[[Category: U6 rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:02:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:04:23 2008''

Revision as of 13:04, 28 July 2008

Image:1xhp.png

Template:STRUCTURE 1xhp

Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae

Template:ABSTRACT PUBMED 15543154

About this Structure

Full experimental information is available from OCA.

Reference

U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction., Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE, Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Epub 2004 Nov 14. PMID:15543154

Page seeded by OCA on Mon Jul 28 16:04:23 2008

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