1yba

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{{STRUCTURE_1yba| PDB=1yba | SCENE= }}
{{STRUCTURE_1yba| PDB=1yba | SCENE= }}
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'''The active form of phosphoglycerate dehydrogenase'''
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===The active form of phosphoglycerate dehydrogenase===
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==Overview==
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An active conformation of phosphoglycerate dehydrogenase (PGDH) from Escherichia coli has been obtained using X-ray crystallography. The X-ray crystal structure is used to examine the potential intermediates for V(max) regulation, for the redox reaction, and for cooperative effects of serine binding. The crystal structure at 2.2 A resolution contains bound NAD(+) cofactor, either sulfate or phosphate anions, and alpha-ketoglutarate, a nonphysiological substrate. A PGDH subunit is formed from three distinct domains: regulatory (RBD), substrate (SBD), and nucleotide binding (NBD). The crystal conformation of the homotetramer points to the fact that, in the absence of serine, coordinated movement of the RBD-SBD domains occurs relative to the NBD. The result is a conformational change involving the steric relationships of both the domains and the subunits. Within the active site of each subunit is a bound molecule of alpha-ketoglutarate and the coenzyme, NAD. The catalytic or active site cleft is changed slightly although it is still solvent exposed; therefore, the catalytic reaction probably involves additional conformational changes. By comparing the inhibited with the uninhibited complex, it is possible to describe changes in conformation that are involved in the inhibitory signal transduction of serine.
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(as it appears on PubMed at http://www.pubmed.gov), where 15823035 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15823035}}
==About this Structure==
==About this Structure==
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[[Category: Thompson, J R.]]
[[Category: Thompson, J R.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:06:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:06:18 2008''

Revision as of 13:06, 28 July 2008

Image:1yba.png

Template:STRUCTURE 1yba

The active form of phosphoglycerate dehydrogenase

Template:ABSTRACT PUBMED 15823035

About this Structure

1YBA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Vmax regulation through domain and subunit changes. The active form of phosphoglycerate dehydrogenase., Thompson JR, Bell JK, Bratt J, Grant GA, Banaszak LJ, Biochemistry. 2005 Apr 19;44(15):5763-73. PMID:15823035

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