This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1n9a
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1n9a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n9a, resolution 3.20Å" /> '''Farnesyltransferase ...)
Next diff →
Revision as of 19:57, 20 November 2007
|
Farnesyltransferase complex with tetrahydropyridine inhibitors
Overview
Inhibitors of farnesyltransferase are effective against a variety of, tumors in mouse models of cancer. Clinical trials to evaluate these agents, in humans are ongoing. In our effort to develop new farnesyltransferase, inhibitors, we have discovered bioavailable aryl tetrahydropyridines that, are potent in cell culture. The design, synthesis, SAR and biological, properties of these compounds will be discussed.
About this Structure
1N9A is a Protein complex structure of sequences from Rattus norvegicus with ZN, HFP and FTI as ligands. Full crystallographic information is available from OCA.
Reference
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency., Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1363-6. PMID:12657283
Page seeded by OCA on Tue Nov 20 22:04:15 2007
Categories: Protein complex | Rattus norvegicus | Cohen, J. | Conner, S.J.O. | Gu, W.Z. | Hasvold, L. | II, S.L.Gwaltney. | Imade, H. | Li, Q. | Nelson, L.T. | Sullivan, G.M. | Wang, W. | FTI | HFP | ZN | Farnesyltransferase | Prenyltransferase | Tetrahydropyridine
