2iyk

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{{STRUCTURE_2iyk| PDB=2iyk | SCENE= }}
{{STRUCTURE_2iyk| PDB=2iyk | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE UPF2-INTERACTING DOMAIN OF NONSENSE MEDIATED MRNA DECAY FACTOR UPF1'''
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===CRYSTAL STRUCTURE OF THE UPF2-INTERACTING DOMAIN OF NONSENSE MEDIATED MRNA DECAY FACTOR UPF1===
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==Overview==
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UPF1 is an essential eukaryotic RNA helicase that plays a key role in various mRNA degradation pathways, notably nonsense-mediated mRNA decay (NMD). In combination with UPF2 and UPF3, it forms part of the surveillance complex that detects mRNAs containing premature stop codons and triggers their degradation in all organisms studied from yeast to human. We describe the 3 A resolution crystal structure of the highly conserved cysteine-histidine-rich domain of human UPF1 and show that it is a unique combination of three zinc-binding motifs arranged into two tandem modules related to the RING-box and U-box domains of ubiquitin ligases. This UPF1 domain interacts with UPF2, and we identified by mutational analysis residues in two distinct conserved surface regions of UPF1 that mediate this interaction. UPF1 residues we identify as important for the interaction with UPF2 are not conserved in UPF1 homologs from certain unicellular parasites that also appear to lack UPF2 in their genomes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16931876 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16931876}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:04:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:09:28 2008''

Revision as of 13:09, 28 July 2008

Image:2iyk.png

Template:STRUCTURE 2iyk

CRYSTAL STRUCTURE OF THE UPF2-INTERACTING DOMAIN OF NONSENSE MEDIATED MRNA DECAY FACTOR UPF1

Template:ABSTRACT PUBMED 16931876

About this Structure

2IYK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1., Kadlec J, Guilligay D, Ravelli RB, Cusack S, RNA. 2006 Oct;12(10):1817-24. Epub 2006 Aug 24. PMID:16931876

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