2gaj

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{{STRUCTURE_2gaj| PDB=2gaj | SCENE= }}
{{STRUCTURE_2gaj| PDB=2gaj | SCENE= }}
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'''Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form'''
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===Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form===
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==Overview==
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DNA topoisomerases are a family of enzymes altering the topology of DNA by concerted breakage and rejoining of the phosphodiester backbone of DNA. Bacterial and archeal type IA topoisomerases, including topoisomerase I, topoisomerase III, and reverse gyrase, are crucial in regulation of DNA supercoiling and maintenance of genetic stability. The crystal structure of full length topoisomerase I from Thermotoga maritima was determined at 1.7A resolution and represents an intact and fully active bacterial topoisomerase I. It reveals the torus-like structure of the conserved transesterification core domain comprising domains I-IV and a tightly associated C-terminal zinc ribbon domain (domain V) packing against domain IV of the core domain. The previously established zinc-independence of the functional activity of T.maritima topoisomerase I is further supported by its crystal structure as no zinc ion is bound to domain V. However, the structural integrity is preserved by the formation of two disulfide bridges between the four Zn-binding cysteine residues. A functional role of domain V in DNA binding and recognition is suggested and discussed in the light of the structure and previous biochemical findings. In addition, implications for bacterial topoisomerases I are provided.
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(as it appears on PubMed at http://www.pubmed.gov), where 16600296 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16600296}}
==About this Structure==
==About this Structure==
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[[Category: Topoisomerase]]
[[Category: Topoisomerase]]
[[Category: Zinc ribbon]]
[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:53:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:13:45 2008''

Revision as of 13:13, 28 July 2008

Image:2gaj.png

Template:STRUCTURE 2gaj

Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form

Template:ABSTRACT PUBMED 16600296

About this Structure

2GAJ is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of full length topoisomerase I from Thermotoga maritima., Hansen G, Harrenga A, Wieland B, Schomburg D, Reinemer P, J Mol Biol. 2006 May 19;358(5):1328-40. Epub 2006 Mar 23. PMID:16600296

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