2q09

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{{STRUCTURE_2q09| PDB=2q09 | SCENE= }}
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'''Crystal structure of Imidazolonepropionase from environmental sample with bound inhibitor 3-(2,5-Dioxo-imidazolidin-4-yl)-propionic acid'''
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===Crystal structure of Imidazolonepropionase from environmental sample with bound inhibitor 3-(2,5-Dioxo-imidazolidin-4-yl)-propionic acid===
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==Overview==
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Imidazolonepropionase (HutI) (imidazolone-5-propanote hydrolase, EC 3.5.2.7) is a member of the amidohydrolase superfamily and catalyzes the conversion of imidazolone-5-propanoate to N-formimino-L-glutamate in the histidine degradation pathway. We have determined the three-dimensional crystal structures of HutI from Agrobacterium tumefaciens (At-HutI) and an environmental sample from the Sargasso Sea Ocean Going Survey (Es-HutI) bound to the product [ N-formimino-L-glutamate (NIG)] and an inhibitor [3-(2,5-dioxoimidazolidin-4-yl)propionic acid (DIP)], respectively. In both structures, the active site is contained within each monomer, and its organization displays the landmark feature of the amidohydrolase superfamily, showing a metal ligand (iron), four histidines, and one aspartic acid. A catalytic mechanism involving His265 is proposed on the basis of the inhibitor-bound structure. This mechanism is applicable to all HutI forms.
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(as it appears on PubMed at http://www.pubmed.gov), where 18442260 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18442260}}
==About this Structure==
==About this Structure==
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[[Category: Psi-2 community]]
[[Category: Psi-2 community]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:17:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:13:47 2008''

Revision as of 13:13, 28 July 2008

Image:2q09.png

Template:STRUCTURE 2q09

Crystal structure of Imidazolonepropionase from environmental sample with bound inhibitor 3-(2,5-Dioxo-imidazolidin-4-yl)-propionic acid

Template:ABSTRACT PUBMED 18442260

About this Structure

Full crystallographic information is available from OCA.

Reference

A common catalytic mechanism for proteins of the HutI family., Tyagi R, Eswaramoorthy S, Burley SK, Raushel FM, Swaminathan S, Biochemistry. 2008 May 20;47(20):5608-15. Epub 2008 Apr 29. PMID:18442260

Page seeded by OCA on Mon Jul 28 16:13:47 2008

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