2d9q

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{{STRUCTURE_2d9q| PDB=2d9q | SCENE= }}
{{STRUCTURE_2d9q| PDB=2d9q | SCENE= }}
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'''Crystal Structure of the Human GCSF-Receptor Signaling Complex'''
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===Crystal Structure of the Human GCSF-Receptor Signaling Complex===
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==Overview==
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A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 A resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6/gp130 signaling complex. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses.
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The line below this paragraph, {{ABSTRACT_PUBMED_16492764}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16492764 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16492764}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex., Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16492764 16492764]
Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex., Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16492764 16492764]
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Thermodynamic analysis of the activation mechanism of the GCSF receptor induced by ligand binding., Mine S, Koshiba T, Honjo E, Okamoto T, Tamada T, Maeda Y, Matsukura Y, Horie A, Ishibashi M, Sato M, Azuma M, Tokunaga M, Nitta K, Kuroki R, Biochemistry. 2004 Mar 9;43(9):2458-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14992583 14992583]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Ligand-receptor complex]]
[[Category: Ligand-receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:57:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:17:50 2008''

Revision as of 13:17, 28 July 2008

Image:2d9q.png

Template:STRUCTURE 2d9q

Crystal Structure of the Human GCSF-Receptor Signaling Complex

Template:ABSTRACT PUBMED 16492764

About this Structure

2D9Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex., Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:16492764

Thermodynamic analysis of the activation mechanism of the GCSF receptor induced by ligand binding., Mine S, Koshiba T, Honjo E, Okamoto T, Tamada T, Maeda Y, Matsukura Y, Horie A, Ishibashi M, Sato M, Azuma M, Tokunaga M, Nitta K, Kuroki R, Biochemistry. 2004 Mar 9;43(9):2458-64. PMID:14992583

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