1mtl

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[[Image:1mtl.jpg|left|200px]]
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{{Seed}}
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[[Image:1mtl.png|left|200px]]
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{{STRUCTURE_1mtl| PDB=1mtl | SCENE= }}
{{STRUCTURE_1mtl| PDB=1mtl | SCENE= }}
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'''Non-productive MUG-DNA complex'''
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===Non-productive MUG-DNA complex===
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==Overview==
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Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.
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The line below this paragraph, {{ABSTRACT_PUBMED_9699633}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9699633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9699633}}
==About this Structure==
==About this Structure==
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[[Category: Inter-strand]]
[[Category: Inter-strand]]
[[Category: Non-productive]]
[[Category: Non-productive]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:21:09 2008''

Revision as of 13:21, 28 July 2008

Image:1mtl.png

Template:STRUCTURE 1mtl

Non-productive MUG-DNA complex

Template:ABSTRACT PUBMED 9699633

About this Structure

1MTL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:9699633

Page seeded by OCA on Mon Jul 28 16:21:09 2008

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