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1nxn

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[[Image:1nxn.gif|left|200px]]
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{{STRUCTURE_1nxn| PDB=1nxn | SCENE= }}
{{STRUCTURE_1nxn| PDB=1nxn | SCENE= }}
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'''SOLUTION STRUCTURE OF CONTRYPHAN-VN'''
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===SOLUTION STRUCTURE OF CONTRYPHAN-VN===
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==Overview==
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The solution structure of contryphan-Vn, a cyclic peptide with a double cysteine S-S bridge and containing a D-tryptophan extracted from the venom of the cone snail Conus ventricosus, has been determined by NMR spectroscopy using a variety of homonuclear and heteronuclear NMR methods and restrained molecular dynamics simulations. The main conformational features of backbone contryphan-Vn are a type IV beta-turn from Gly 1 to Lys 6 and a type I beta-turn from Lys 6 to Cys 9. As already found in other contryphans, one of the two prolines--the Pro4--is mainly in the cis conformation while Pro7 is trans. A small hydrophobic region probably partly shielded from solvent constituted from the close proximity of side chains of Pro7 and Trp8 was observed together with a persistent salt bridge between Asp2 and Lys6, which has been revealed by the diagnostic observation of specific nuclear Overhauser effects. The salt bridge was used as a restraint in the molecular dynamics in vacuum but without inserting explicit electrostatic contribution in the calculations. The backbone of the unique conformational family found of contryphan-Vn superimposes well with those of contryphan-Sm and contryphan-R. This result indicates that the contryphan structural motif represents a robust and conserved molecular scaffold whose main structural determinants are the size of the intercysteine loop and the presence and location in the sequence of the D-Trp and the two Pro residues.
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{{ABSTRACT_PUBMED_15150794}}
==About this Structure==
==About this Structure==
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This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1n3v 1n3v]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXN OCA].
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This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1n3v 1n3v]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXN OCA].
==Reference==
==Reference==
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[[Category: Disulfide bridge]]
[[Category: Disulfide bridge]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:06:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:21:30 2008''

Revision as of 13:21, 28 July 2008

Image:1nxn.png

Template:STRUCTURE 1nxn

SOLUTION STRUCTURE OF CONTRYPHAN-VN

Template:ABSTRACT PUBMED 15150794

About this Structure

This structure supersedes the now removed PDB entry 1n3v. Full experimental information is available from OCA.

Reference

Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator., Eliseo T, Cicero DO, Romeo C, Schinina ME, Massilia GR, Polticelli F, Ascenzi P, Paci M, Biopolymers. 2004 Jun 15;74(3):189-98. PMID:15150794

Page seeded by OCA on Mon Jul 28 16:21:30 2008

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