1q8l

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{{STRUCTURE_1q8l| PDB=1q8l | SCENE= }}
{{STRUCTURE_1q8l| PDB=1q8l | SCENE= }}
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'''Second Metal Binding Domain of the Menkes ATPase'''
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===Second Metal Binding Domain of the Menkes ATPase===
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==Overview==
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Biological utilisation of copper requires that the metal, in its ionic forms, be meticulously transported, inserted into enzymes and regulatory proteins, and excess be excreted. To understand the trafficking process, it is crucial that the structures of the proteins involved in the varied processes be resolved. To investigate copper binding to a family of structurally related copper-binding proteins, we have characterised the second Menkes N-terminal domain (MNKr2). The structure, determined using 1H and 15N heteronuclear NMR, of the reduced form of MNKr2 has revealed two alpha-helices lying over a single beta-sheet and shows that the binding site, a Cys(X)2Cys pair, is located on an exposed loop. 1H-15N HSQC experiments demonstrate that binding of Cu(I) causes changes that are localised to conserved residues adjacent to the metal binding site. Residues in this area are important to the delivery of copper by the structurally related Cu(I) chaperones. Complementary site-directed mutagenesis of the adjacent residues has been used to probe the structural roles of conserved residues.
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{{ABSTRACT_PUBMED_14572476}}
==About this Structure==
==About this Structure==
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1Q8L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8L OCA].
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1Q8L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8L OCA].
==Reference==
==Reference==
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[[Category: Jones, C E.]]
[[Category: Jones, C E.]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:00:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:26:15 2008''

Revision as of 13:26, 28 July 2008

Image:1q8l.png

Template:STRUCTURE 1q8l

Second Metal Binding Domain of the Menkes ATPase

Template:ABSTRACT PUBMED 14572476

About this Structure

1Q8L is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and metal binding studies of the second copper binding domain of the Menkes ATPase., Jones CE, Daly NL, Cobine PA, Craik DJ, Dameron CT, J Struct Biol. 2003 Sep;143(3):209-18. PMID:14572476

Page seeded by OCA on Mon Jul 28 16:26:15 2008

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