1pmd

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{{STRUCTURE_1pmd| PDB=1pmd | SCENE= }}
{{STRUCTURE_1pmd| PDB=1pmd | SCENE= }}
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'''PENICILLIN-BINDING PROTEIN 2X (PBP-2X)'''
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===PENICILLIN-BINDING PROTEIN 2X (PBP-2X)===
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==Overview==
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All beta-lactam antibiotics exert their biological effects by interacting with a unique class of proteins, the penicillin-binding proteins (PBPs). These membrane proteins are involved in the biosynthesis of the murein or peptidoglycan, a mesh-like structure which completely surrounds the bacterial cell. Sequence similarities indicate that one domain of these proteins belongs to a large family of beta-lactam-recognizing proteins, which includes the active-site serine beta-lactamases. We here report the first three-dimensional crystal structure of a high molecular weight penicillin-binding protein, PBP2x of Streptococcus pneumoniae, at 3.5 A resolution. The molecule has three domains, the central domain being a transpeptidase, which is a suitable target for antibiotic development.
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{{ABSTRACT_PUBMED_8605631}}
==About this Structure==
==About this Structure==
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[[Category: Resistance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:26:52 2008''

Revision as of 13:26, 28 July 2008

Image:1pmd.png

Template:STRUCTURE 1pmd

PENICILLIN-BINDING PROTEIN 2X (PBP-2X)

Template:ABSTRACT PUBMED 8605631

About this Structure

1PMD is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme., Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O, Nat Struct Biol. 1996 Mar;3(3):284-9. PMID:8605631

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