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2nmt

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[[Image:2nmt.jpg|left|200px]]
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{{STRUCTURE_2nmt| PDB=2nmt | SCENE= }}
{{STRUCTURE_2nmt| PDB=2nmt | SCENE= }}
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'''MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS'''
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===MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS===
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==Overview==
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N-myristoyltransferase (Nmt) attaches myristate to the N-terminal glycine of many important eukaryotic and viral proteins. It is a target for anti-fungal and anti-viral therapy. We have determined the structure, to 2.9 A resolution, of a ternary complex of Saccharomyces cerevisiae Nmt1p with bound myristoylCoA and peptide substrate analogs. The model reveals structural features that define the enzyme's substrate specificities and regulate the ordered binding and release of substrates and products. A novel catalytic mechanism is proposed involving deprotonation of the N-terminal ammonium of a peptide substrate by the enzyme's C-terminal backbone carboxylate.
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(as it appears on PubMed at http://www.pubmed.gov), where 9846880 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9846880}}
==About this Structure==
==About this Structure==
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[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
[[Category: Transferase acyltransferase]]
[[Category: Transferase acyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:36:35 2008''

Revision as of 13:36, 28 July 2008

Image:2nmt.png

Template:STRUCTURE 2nmt

MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS

Template:ABSTRACT PUBMED 9846880

About this Structure

2NMT is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs., Bhatnagar RS, Futterer K, Farazi TA, Korolev S, Murray CL, Jackson-Machelski E, Gokel GW, Gordon JI, Waksman G, Nat Struct Biol. 1998 Dec;5(12):1091-7. PMID:9846880

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