2a0l

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{{STRUCTURE_2a0l| PDB=2a0l | SCENE= }}
{{STRUCTURE_2a0l| PDB=2a0l | SCENE= }}
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'''Crystal structure of KvAP-33H1 Fv complex'''
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===Crystal structure of KvAP-33H1 Fv complex===
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==Overview==
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Voltage-dependent ion channels gate open in response to changes in cell membrane voltage. This form of gating permits the propagation of action potentials. We present two structures of the voltage-dependent K(+) channel KvAP, in complex with monoclonal Fv fragments (3.9 A) and without antibody fragments (8 A). We also studied KvAP with disulfide cross-bridges in lipid membranes. Analyzing these data in the context of the crystal structure of Kv1.2 and EPR data on KvAP we reach the following conclusions: (i) KvAP is similar in structure to Kv1.2 with a very modest difference in the orientation of its voltage sensor; (ii) mAb fragments are not the source of non-native conformations of KvAP in crystal structures; (iii) because KvAP contains separate loosely adherent domains, a lipid membrane is required to maintain their correct relative orientations, and (iv) the model of KvAP is consistent with the proposal of voltage sensing through the movement of an arginine-containing helix-turn-helix element at the protein-lipid interface.
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{{ABSTRACT_PUBMED_16223877}}
==About this Structure==
==About this Structure==
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[[Category: Voltage sensor]]
[[Category: Voltage sensor]]
[[Category: Voltage-dependent k+ channel]]
[[Category: Voltage-dependent k+ channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:27:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:38:53 2008''

Revision as of 13:39, 28 July 2008

Image:2a0l.png

Template:STRUCTURE 2a0l

Crystal structure of KvAP-33H1 Fv complex

Template:ABSTRACT PUBMED 16223877

About this Structure

2A0L is a Single protein structure of sequence from Aeropyrum pernix and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane., Lee SY, Lee A, Chen J, MacKinnon R, Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15441-6. Epub 2005 Oct 13. PMID:16223877

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